Trusted Research Environments Health data used for research and innovation comes from a variety of sources, but most relates to peoples’ interaction with the health and care system in some way – for example as an NHS patient, a participant in a clinical trial, being involved in a genomics initiative or as a blood donor. Whilst none of this data is stored on the Gateway, achieving the confidence and trust of patients and the public in the use of this data is central to achieving our vision. Trusted (or Trustworthy) Research Environments (TREs) protect - by design- the privacy of individuals whose health data they hold, while facilitating large scale data analysis using High Performance Computing that increases understanding of disease and improvements in health and care.